Her present research interest includes cellular immunology particularly NK cell activity in hepatocarcinoma and NK receptor signaling. She has also pioneered interdisciplinary research in the field of CFD analysis with body fluids in collaboration with the Mechanical Engineering dept at DTU and IIT Delhi.

She is also engaged in collaborative research in the field of Cancer Biology with Industry and other academic institutes like JNU, NII and others.  

Research areas pursued in the lab:

• Several reports have previously shown that NK cells in specific organs like liver, uterus and lungs show hypo-activity compared to peripheral NK. We are engaged in finding the basis for this altered NK activity and also tumour mediated alteration in NK profile in these organs.
• To study the regulation of Natural Killer cell activity and receptor expression.
• The tumour cells also employ various strategies to evade the immune system and in our laboratory we study tumour cell expressed ligand induced NK cell activity modulation.
• Evaluating the role of inflammation in cancer therapy.
• In-silico analysis of natural products for potential combinatorial cancer therapy by immunomodulation and developing drug delivery systems
• Role of HLA haplotype profile in Cancer Epidemiology.
• Role of autophagy in cancer therapeutics.

Interdisciplinary research:

1.    With IIT Mechanical Engineering

Use of Computational Fluid dynamics in diagnostics of Autoimmune diseases.

Presently autoimmune diseases are generally detected at an advanced stage and since the therapy involves immunosuppression, prolonged therapy has various serious side effects. My lab is collaborating with mechanical engineering department to adapt Computational Fluid Dynamics algorithm to be able to diagnose Autoimmune disorders at early stages.

2.    With Civil Engineering (DTU)

Development of Bacterial Concrete

Post construction damage is often due to formation of pores in concrete structures due to wear and tear and hence our lab is engaged in interdisciplinary research in conjunction with Department of Civil Engineering in optimizing bacterial culture in concrete preparations that will minimize pore formations and also affect losses due to postconstruction damage.

SPONSORED RESEARCH PROJECTS:

1. Principal Investigator:  Tumor cell mediated Immunomodulation funded by DST for Rs 20.2L

2. Principal Investigator: Preparation of tumor targeting monoclonal Antibody and Crocin nanoparticle conjugate for drug delivery system (DTU research grant)

3. Co investigator: Studies on elucidating Silver Nanoparticle as potent inhibitor of hyphal morphogenesis and drug resistance in opportunistic fungal pathogen, Candida and potential host cell toxicity  funded by UPE JNU for Rs 11L 

PHD STUDENTS GUIDED: 5 (degrees awarded) 2 (submitted)

PUBLICATIONS:

1. Kim H. S., Das A., Gross C., Bryceson Y.T., Long E.O. (2010) Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl. Immunity 32(2) 175-186.ISSN:1074-7613(Impact factor: 43.4)
2. Madhuri Chaurasia, Asmita Das*, B.S. Dwarakanath, Anne Simonsen, Kulbhushan Sharma (Supervisor)(2019)Radiation induces EIF 2AK3/PERK and ERN1/Ire1 mediated pro-survival autophagy. Autophagy, 2019 Feb 17 (8):1391-1406. doi: 10.1080/15548627.2019.1582973 Taylor and Francis publication ISSN:1554-8627 Impact Factor 16.02
3. Das, A. and Long E.O. Granule polarization in NK cells is a better target for inhibition than degranulation.(2010) Journal of Immunology 185, 4698-4704. ISSN:0022-1767(Selected among the top 10% articles published in the journal in 2010). (Impact factor: 5.7)
4. Ritu, Prakash Chandra and Asmita Das* (2023) (*Corresponding author) Cholinergic side effect-free anticancer drugs: paving the way for safer and more effective cancer treatment. Journal of Biomolecular Structure and Dynamics ISSN:0739-1102. Impact factor:4.4
5. Ritu, Prakash Chandra and Asmita Das* (2023) (*Corresponding author) Immune checkpoint targeting antibodies hold promise for combinatorial cancer therapeutics. Clinical and experimental medicine. ISSN: 1591-9528. Impact factor:4.6
6. Bhasin S, Das A. (2023) Marine alkaloid rigidin analogues as potential selective inhibitors of SHP1, a new strategy for cancer immunotherapeutics.J Biomol Structure and Dynamics. 2023 Jun 22:1-17. doi: 10.1080/07391102.2023.2227708. ISSN: 1538-0254. Impact factor: 5.2
7. Kashyap S, Das Asmita.(2023) Exploring the complex and multifaceted interplay of the gut microbiome and cancer prevention and therapy. Acta Microbiol Immunol Hung. Jun 12;70(2):85-99. doi: 10.1556/030.2023.02054. ISSN: 12178950. Impact factor:1.3
8. Shweta Gulia, Prakash Chandra and Asmita Das* (2023) (*Corresponding author) The Prognosis of Cancer Depends on the Interplay of Autophagy, Apoptosis, and Anoikis within the Tumor Microenvironment. Cell biochemistry and biophysics. ISSN:1085-9195. Impact factor: 2.6
9. Himanshi Singh, Asmita Das, Mohammad Moshahid Khan and Tayebeh Pourmotabbed (2023) New insights into the therapeutic approaches for the treatment of taupathies. Neural Regeneration Research. ISSN: 1673-5374. Impact Factor: 6.05
10. Saksham Garg, Nikita Sharma, Bharmjeet and Asmita Das* (*Corresponding author) (2023)Unraveling the intricate relationship: Influence of microbiomeon the host immune system in carcinogenesis. Cancer Reports (Wiley Publication) pg-1-12. http://doi.org/10.1002/cnr2.1892  ISSN 2573-8348. Impact factor 1.7
11. Ritu, Krishan Kumar Verma, Asmita Das, Prakash Chandra. (2023)Phytochemical‐Based Synthesis of Silver Nanoparticle: Mechanism and Potential Applications. BioNano Science (Springer Publication) ISSN: 2191-1630 Impact Factor:3
12. Sunil Kumar and Asmita Das* (*Corresponding author) (2023)A Cocktail of Natural Compounds Holds Promise for New Immunotherapeutic Potential in Head and Neck Cancer. Chinese Journal of Integrative Medicine (Springer Publication) ISSN:1672-0415 Impact Factor:2.6
13. Sunil Kumar and Asmita Das* (*Corresponding author) (2023)Peripheral blood mononuclear cell derived biomarker detection using eXplainable Artificial Intelligence (XAI) provides better diagnosis of breast cancer. Computational Biology and Chemistry (Elsevier publications) ISSN: 1476-9271. Impact Factor:3.7
14. Yuvraj Sharma and Asmita Das* (*Corresponding author) (2023) Targeting aging associated pathways: a novel therapeutic approach for cancer. Vegetos (Springer publication) ISSN:2229-4473. 
15. Bharmjeet and Asmita Das* (*Corresponding author) (2023)Racial disparities in cancer care, an eyeopener for developing better global cancer management strategies. Cancer Reports (Wiley Publication) ISSN: 2573-8348.
16. Preksha Jain and Asmita Das* (*Corresponding author) (2023) Identifying tinospora cordifolia bioactivecompounds with the greatest inflammatory therapeutic potential. International Journal of Advances in Science Engineering and Technology. Vol 11, Issue 2, Pg 2321-8991. ISSN 2321-8991.
17. Namit Dey, Deenan Santhiya and Asmita Das (2023) One-Pot synthesis of Doxorubicin-bioactive glass ceramic hybrid nanoparticles through a bio-inspired route for anti cancer therapy. Chemistry Select (Wiley publication) ISSN: 2365-6549 Impact factor: 2.3
18. Dr. Asmita Das Editor of Book, “Microbial Crosstalk with Immune System” published by Elsevier Publication ISBN: 9780323961288 (2022)
19. Dr. Asmita Das Editor of Book, “Proceedings of International Conference on Innovations in Biotechnology and Life Sciences” published by INSHA Publication ISBN: 978-93-88647-32-8 (2020)
20. Muskaan Dhingra, Shayon Mahalanobis and Asmita Das* (*Corresponding author) (2022) Thyroid receptor B might be responsible for breast cancer associated with Hashimoto’s thyroiditis: a new insight into pathogenesis. (2022) Immunologic Research, Springer, Vol 70, 441-448. ISSN: 0257-277X Impact Factor 4.5
21. Gunjan Sachdeva and Asmita Das* (*Corresponding author) (2022) Communication between immune system and mycobiota impacts health and disease. Proc. Indian Natl. Sci. Acad.(Springer) 88; 250-262doi: 10.1007/s43538-022-00082-5 ISSN: 0370-0046 (Impact Factor: 0.3)
22. Namit Dey, Deenan Santhiya and Asmita Das (2022) Bio-Inspired Synthesis of Hollow Mesoporous Bioactive Glass Nanoparticles Using Calcium Carbonate as Solid Template. Chemistry Select. 7,12, 1-7. ISSN 2365-6549. Impact factor 2.3
23. Amit Mathur, Vikas Dhikav, Bhargavi Jadeja, and Asmita Das (2021) Digital device usage and subjective memory complaints during COVID-19 pandemic among young adults. J Neurol Sci.Oct; 429: 119062 doi: 10.1016/j.jns.2021.119062
24. Priyanka Rawat and Asmita Das* (*Corresponding author) (2022) Differential expression of disparate transcription factor regime holds the key for NK cell development and function modulation. Life Sciences 297, 120471(Elsevier). ISSN 0024-3205 (Impact Factor:6.7) 
25. Sunil Kumar and Asmita Das* (*Corresponding author) (2022) Elucidation of natural compounds Gallic acid and Shikonin for the treatment of HNSC cancer by targeting immune suppressor and tumour progression genes. Vegetos, Springer publications 35; 880-894. ISSN: 2229-4473https://doi.org/10.1007/s42535-022-00363-w
26. Saksham Garg, Sunil Kumar, Ashutosh Anand, Tarunya Menon, Nikita Sharma, Japneet Singh, Siddharth Chawla and Asmita Das* (*Corresponding author) (2022)Plant derived natural compounds aiding SOCS1 mediated JAK1 inhibition, a novel mechanism of combinatorial cancer chemotherapy. Vegetos, Springer publications 35; 707-722 ISSN: 2229-4473
27. Ritika Luthra, Shreeja Datta and Asmita Das* (*Corresponding author) (2022) Mathematical Models are Crucial in Development of Novel Strategies for Cancer Treatment. Research Journal of Biotechnology. Vol 17 (6) 204-219. ISSN: 09736263 (IF:0.4) 
28. Niharika Gupta, Shine Augustine, Tarun Narayan, Alan O’Riordan, Asmita Das, D. Kumar, John H. T. Luong, Bansi D. Malhotra (2021) Point-of-Care PCR Assays for COVID-19 Detection. Biosensors (Basel) 2021 May; 11(5): 141 ISSN 2079-6374 (IF:5.7)
29. Reetika Singh and Asmita Das* (*Corresponding author) (2021) The Role of TLRs in the Immunomodulation of Tumor Microenvironment. Research Journal of Biotechnology. Vol 17(2)173-180. ISSN: 09736263 (IF:0.4)
30. Sneha Iyer and Asmita Das* (*Corresponding author) (2021) Stem Cell Therapy for infectious diseases like COVID 19 - A Review. Journal of Stem Cells. Vol 16, No.2-3. 73-90. ISSN 1556-8539
31. Sneha Iyer and Asmita Das (2021) Responsive nanogel for anti-cancer therapy. Materials Today: Proceedings. Vol 44, Part 1, pg 2330-2333 (Elsevier Publication) ISSN 2214-7853
32. Reeya Tanwar and Asmita Das (2021) Identification of Drug targets for AKT-1 in Proteus syndrome in silico docking studies. IJASET 9; 3; 34-38 ISSN:2321 –8991
33. Sneha Iyer and Asmita Das (2020) Targeting Wnt Pathway in Cancer Stem Cells for anti cancer therapy. International Journal of Advances in Science, Engineering and Technology. Vol 8; 4; pg 4-7 ISSN 2321-8991
34. Bhatia K, Bhumika and Das Asmita* (*Corresponding author) In silico analysis of drug molecules to perform drug repurposing against variety of cancer targets. IJASEAT (2020) Vol 8, Issue 3; pg 35-41.ISSN 2321-8991. 
35. Shaleen Jain and AsmitaDas* (*Corresponding author) Virtual screening of natural compounds as combinatorial agents from Indian medicinal plants against estrogen positive breast cancer. International Journal of Integrated Education(2020)Vol 3, No.10; 266-275 ISSN 2620-3502 
36. Sachin Singh and Asmita Das (2020) Study of Brain Region Segmentation using Convolutional Neural Network. International Journal on Orange Technologies. Vol 2; Issue 10; Pg 66-75. ISSN 2615-7071
37. Bhatia K, Bhumika, Das Asmita* (*Corresponding author) Combinatorial drug therapy in cancer-New insights. Life Sciences (Elsevier) ISSN 0024-3205 (2020) Vol 258, 118134 (Impact Factor 6.7)
38. Kumari N, Das A, Bhatt A (2020) Interleukin-6 confers radio-resistance by inducing Akt mediated glycolysis and reducing mitochondrial damage in cells. Journal of Biochemistry (Oxford Univ Press) 167; 3. Pg 303-314 ISSN 1756-2651, doi: 10.1093/jb/mvz091. [Epub ahead of print] Impact Factor: 3.4
39. Mylavarapu S, Kumar H, Kumari S, Sravanthi LS, Jain M, Basu A, Biswas M, Mylavarapu SVS, Das A*, Roy M*(*Corresponding author).Activation of Epithelial-Mesenchymal Transition and Altered β-Catenin Signaling in a Novel Indian Colorectal Carcinoma Cell Line.Front Oncol. 2019 Feb 15;9:54. Impact Factor 6.2 ISSN 2234-943X
40. Vani Venugopal and Asmita Das* (*corresponding author) (2019)Elucidating the mechanism of action of Crocin, a therapeutic agent for cancer and inflammation. International Journal of biotechnology and Biomedical Sciences. Vol 5; 1; 48-52. ISSN: 2454-4592
41. Sunil Kumar and Asmita Das* (*corresponding author) (2019) Therapeutic target prediction of tumor specific antigen for vaccine design International Journal of biotechnology and Biomedical Sciences. Vol 5; 1; 57-60. ISSN: 2454-4592
42. Sharma R, Das A*.(*corresponding author)(2018) In silico approach to study affinity of NK cell inhibitory receptor interaction with classical and non classical ligands Archives of Immunology and Allergy 1, (2) 40-53 ISSN: 2639-1848
43. Mylavarapu S, Das A*, Roy M.(2018)(*Supervisor)Role of BRCA Mutations in the Modulation of Response to Platinum Therapy.Frontiers in Oncology 8(16). Doi:0.3389/fonc.2018.00016. Ecollection 2018.ISSN: 2234-943X Impact factor 6.2
44. Sharma R, Das A*. (*corresponding author)(2018) IL-2 mediates NK cell proliferation but not hyperactivity.Immunol Res. 66(1):151-157. doi: 10.1007/s12026-017-8982-3.Springer Publication ISSN: 0257-277XImpact Factor 4.5
45. Augustine S, Singh J, Srivastava M, Sharma M, Das A, Malhotra BD.(2017) Recent advances in carbon based nanosystems for cancer theranostics. Biomaterial Sci. 5(5):901-952.ISSN 2047-4849 Impact Factor 7.5
46. Dholakia D, Goyal S, Jamal S, Singh A, Das A, Grover A (*Supervisor) Molecular modeling and lead design of substituted zanamivir derivatives as potent anti-influenza drugs BMC Bioinformatics. 2016 Dec 22;17(Suppl 19):512. doi: 10.1186/s12859-016-1374-1.B (Online)ISSN 1471-2105. Impact Factor 3.3
47. Richa Mishra, Ruchi Verma, Sakshi Shreni, Jaspreet Kaur, Divya Joshi, Asmita Das*(*corresponding author) (2016) Evaluating the basis for NK sensitivity and NK resistance in prototypic NK sensitive and resistant cell line. JSM Chemistry 4(4) 1035 ISSN: 2334-1831
48. Kumari N, Dwarakanath B S, Das A*., Bhatt. A.N. (2016) (*Supervisor) Role of IL-6 in cancer progression and therapeutic-resistance. Tumor Biology Sep;37(9):11553-11572. ISSN: 1010-4283 (printversion)1423-0380 (electronic version)(Impact factor: 3.6)
49. Awasthi K., Prasad T and Das A*. (*Corresponding Author)(2016) Detection of multidrug resistant fungal infections in cancer patients (Book Chapter) Molecular Markers in Mycology (Springer)ISBN 978-3-319-34106-4
50. Chaurasia M., Bhatt A., Das A*., Dwarakanath B., Sharma K (2016)(*Supervisor)Radiation induced autophagy: Mechanisms and consequences. Free Radical Research ;50(3):273-90 ISSN: 1071-5762 (Print) 1029-2470 (Online) (Impact Factor: 4.2)
51. Chaurasia M, Misra S., Bhatt A. N., Das A., Dwarakanath B., Sharma K. (2015) (*Supervisor)Metabolic imbalance associated mitophagy in tumor cells: Genesis and implications Journal of Cancer Research Updates, 4, 95-107 ISSN: 1929-2279
52. Das A (corresponding author) and Dhanjal J K. (2015) Medicinal plants, a gold mine of anticancer compounds American International Journal of Research in Formal, Applied & Natural SciencesISSN (Print): 2328-3777, ISSN (Online): 2328-3785, ISSN (CD-ROM): 2328-3793 9(1), December-2014 to February- 2015,14-23.
53. Dhanjal J K, Sharma S., Grover A., Das A* (*corresponding author)(2015)Use of ligand-based pharmacophore modeling and docking approach to find novel acetylcholinesterase inhibitors for treating Alzheimer’s. Biomedicine & Pharmacotherapy 71 (2015) 146–152 Elsevier Publication(Impact factor: 6.5) ISSN: 0753-3322
54. Sharma R and Das A* (*corresponding author) (2014) Organ specific phenotypic and functional features of NK cells in humans. Immunologic Research,58, no. 1, 125-131,Springer Publication(Impact factor: 4.5) ISSN: 0257-277X (DOI 10.1007/s12026-013-8477-9)

BOOKS PUBLISHED

• Dr. Asmita Das Editor of Book, “Microbial Crosstalk with Immune System” published by Elsevier Publication ISBN: 9780323961288 (2022)

• Dr. Asmita Das Editor of Book, “Proceedings of International Conference on Innovations in Biotechnology and Life Sciences” published by INSHA Publication ISBN: 978-93-88647-32-8 (2020)

BOOK CHAPTERS:

• Shayon Mahalanobis, Apoorva, Nikita Sharma,Ritika Luthra, Tarunya Menon and Asmita Das Cancer prognosis and immune system (Chapter 4) Elsevier Publication pg75-114. ISBN: 9780323961288

• Priyanka Rawat, Muskaan Dhingra, Kashish Kosta and Asmita Das Microflora impacts immune system and its antitumor function (Chapter6) Elsevier Publication pg177-199. ISBN: 9780323961288

• Ritu, Shruti Sounkaria, Gunjan Sachdeva, Asmita Das, Smita Rastogi Verma, Saurabh Chandra Saxena, Bhupendra Pratap Singh, Shakilur Rahman and Prakash Chandra. (2023) Book Chapter “Potentialities of nanotechnology in nutrient management in the livestock products” Elsevier Publication, 2023, Pages 111-137, ISBN 9780323983877,https://doi.org/10.1016/B978-0-323-98387-7.00016-1.

• Shweta Gulia, Vanshika Kothari,  Ritu, Smita Rastogi Verma, Asmita Das, Bhupendra Pratap Singh, Prakash Chandra,11 - Bioremediation of PAHs using nanotechnology, Editor(s): Charles Oluwaseun Adetunji, Ravindra Pratap Singh, Jay Singh, Kshitij RB Singh, In Micro and Nano Technologies, Nanobiotechnology for Bioremediation, Elsevier Publication, 2023, Pages 249-271, ISBN 9780323917674, https://doi.org/10.1016/B978-0-323-91767-4.00012-4.

• Das Asmita (2020) (Book Chapter)Isolation of Natural Killer Cells from Mouse Bone Marrow and Spleen. (Chapter 11) Experimental Protocols in Biotechnology (Springer) ISBN 978-1-0716-0607-0 pg 183-192

• Divya Joshi, NausheenTickoo, Chatanya Jain, Asmita Das* (*corresponding author) Advances inCancer Immunity, A Formidable Army (Book Chapter) in Advances in biotechnology ISBN: 978-81-935757-0-3. Chapter1 (pp1-13) (2018)

• Awasthi K., Prasad T and Das A. (Corresponding Author)(2016) Detection of multidrug resistant fungal infections in cancer patients (Book Chapter) Molecular Markers in Mycology (Springer) ISBN 978-3-319-34106-4
• Das A., Dhillon S., and Saxena R.K. (2003) A chapter, “Modulation of NK cell activation by tumor cells: Role of MHC I molecules and their receptors” in book titled “Progress in Haematologic Oncology” published by The Advanced Research Foundation, New York. 

Organizing conferences/workshops:

• Convenor: Student Career Guidance outreach activity- “ Converting Innovation into a startup” organised in DTU on 29th July 2022

• Convenor: International Conference on Innovations in Biotechnology and Life Sciences 18th -20th Dec 2020 (Participants:1200 approx. from more than 20 countries, 500 abstracts approx.)

• Organizing Committee member: DTU sponsored International E-workshop on Bioinformatics 14th-18th Dec 2020

• Organizing Committee member: One day International E-Symposium on Women in Science held on 11th Feb 2021

• Organizing Committee member: “Advanced Pedagogy, IPR, Sponsored Research and Entrepreneurship” organized by Engineering Staff College of India and DTU from 16th to 20th July 2019

• National Conference in Biotechnology and Bioinformatics in DTU (2010)

• India-Japan workshop on “Biomolecular Electronics and Organic Nanotechnology for Environment Preservation” (2013)

Editorial Responsibilities:

• Edited manuscripts as part of Fellows Editorial Board in National Cancer Institute, NIH, USA
• Invited reviewer for PLOS one (impact factor 4.1)
• Editorial Board Member of Journal of Biosciences GSTF, Singapore
• Editorial Board Member of International Association of Innovation Research
• Course on Translational Research in Clinical Oncology conducted by National Cancer Institute (NIH), USA

• Membership of professional societies:

  Life member of the Indian Immunology Society

• Life member of The Indian Science Congress

• AWARDS RECEIVED:

• DTU Research Excellence award reciepient 

• Council of Scientific & Industrial Research (CSIR) (Govt. of India)-Senior Research Fellowship qualified in Nov 2001

• Council of Scientific & Industrial Research (CSIR) (Govt. of India)-NET & Junior Research Fellowship (JRF) qualified in 21 DEC.1997

• Department of Bio-Technology (DBT) scholarship from Govt. of India

• Central Board of Secondary Education (CBSE) National Scholarship in1992